Versatile functionalization of amylopectin for effective biomedical applications
Science China Chemistry, ISSN: 1674-7291, Vol: 58, Issue: 9, Page: 1461-1470
2015
- 22Citations
- 9Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations22
- Citation Indexes22
- 22
- CrossRef12
- Captures9
- Readers9
Article Description
Successful gene vectors should be with high transfection efficiency and minimal cytotoxicity. Natural polysaccharides, due to their good biocompatibility and biodegradability, have been widely studied and applied. Amylopectin is one of polysaccharides with dendritic structure and numerous hydroxyl groups that could be used for subsequent modification. In this work, a series of dendritic cationic gene vectors comprising amylopectin backbones and poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) side chains with different lengths (termed as AMY-PDs) were readily prepared by atom transfer radical polymerization (ATRP). The gene condensation ability, cytotoxicity and gene transfection of AMY-PDs carriers were investigated. In comparison with "gold-standard" poly(ethyleneimine) (PEI, 25 kDa), the AMY-PDs exhibited higher transfection efficiency with lower cytotoxicity. AMY-PDs could be further modified with Au nanoparticles (termed as AMY-PD@Au). The potential of the AMY-PD@Au vectors to be utilized as a CT contrast agent for imaging of cancer cells was investigated. Such AMY-PD@Au vectors may realize gene therapy with the ability of real-time imaging.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84940448117&origin=inward; http://dx.doi.org/10.1007/s11426-015-5327-8; http://link.springer.com/10.1007/s11426-015-5327-8; http://link.springer.com/content/pdf/10.1007/s11426-015-5327-8; http://link.springer.com/content/pdf/10.1007/s11426-015-5327-8.pdf; http://link.springer.com/article/10.1007/s11426-015-5327-8/fulltext.html; http://sciencechina.cn/gw.jsp?action=cited_outline.jsp&type=1&id=5530103&internal_id=5530103&from=elsevier; https://dx.doi.org/10.1007/s11426-015-5327-8; https://link.springer.com/article/10.1007/s11426-015-5327-8
Springer Science and Business Media LLC
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