The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population
Science China Life Sciences, ISSN: 1869-1889, Vol: 57, Issue: 10, Page: 1024-1027
2014
- 3Citations
- 6Captures
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Metrics Details
- Citations3
- Citation Indexes3
- CrossRef1
- Captures6
- Readers6
Article Description
MNS16A, a variable number of tandem repeats polymorphism in the TERT gene, has been suggested to regulate telomerase activity. As telomerase activity has been reported to be related to life-span, we hypothesized that this polymorphism might affect human longevity by controlling the length of the telomere. To test this hypothesis, we collected 446 unrelated pericentenarian individuals (age⩾90, mean 94.45±3.45 years) and 332 normal controls (age 22–53, mean 35.0±12.0 years) from Dujiangyan, Sichuan, China. We typed the MNS16A polymorphism in both groups, and compared the allele and genotype frequencies between the peri-centenarian and control groups using the chi-squared test. There was no significant difference between the peri-centenarian and control groups. Thus, the MNS16A polymorphism in TERT might not influence human life-span, at least in the Han Chinese population studied here.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84920501363&origin=inward; http://dx.doi.org/10.1007/s11427-014-4723-1; http://www.ncbi.nlm.nih.gov/pubmed/25216705; http://link.springer.com/10.1007/s11427-014-4723-1; https://dx.doi.org/10.1007/s11427-014-4723-1; https://link.springer.com/article/10.1007/s11427-014-4723-1
Springer Science and Business Media LLC
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