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The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population

Science China Life Sciences, ISSN: 1869-1889, Vol: 57, Issue: 10, Page: 1024-1027
2014
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Metric Options:   Counts1 Year3 Year

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Article Description

MNS16A, a variable number of tandem repeats polymorphism in the TERT gene, has been suggested to regulate telomerase activity. As telomerase activity has been reported to be related to life-span, we hypothesized that this polymorphism might affect human longevity by controlling the length of the telomere. To test this hypothesis, we collected 446 unrelated pericentenarian individuals (age⩾90, mean 94.45±3.45 years) and 332 normal controls (age 22–53, mean 35.0±12.0 years) from Dujiangyan, Sichuan, China. We typed the MNS16A polymorphism in both groups, and compared the allele and genotype frequencies between the peri-centenarian and control groups using the chi-squared test. There was no significant difference between the peri-centenarian and control groups. Thus, the MNS16A polymorphism in TERT might not influence human life-span, at least in the Han Chinese population studied here.

Bibliographic Details

Liu, LiNa; Wang, ChengYe; Lu, Xiang; Xiao, FuHui; Wang, HuaWei; Yang, LiQin; Xu, LiangYou; Kong, QingPeng

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology; Environmental Science; Agricultural and Biological Sciences

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