Integrin-interacting protein Kindlin-2 induces mammary tumors in transgenic mice
Science China Life Sciences, ISSN: 1674-7305, Vol: 62, Issue: 2, Page: 225-234
2019
- 10Citations
- 16Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations10
- Citation Indexes10
- 10
- CrossRef4
- Captures16
- Readers16
- 16
Article Description
Kindlin-2, an integrin-interacting protein, regulates breast cancer progression. However, currently, no animal model to study the role of Kindlin-2 in the carcinogenesis of mammary gland is available. We established a Kindlin-2 transgenic mouse model using a mammary gland-specific promoter, mammary tumor virus (MMTV) long terminal repeat (LTR). Kindlin-2 was overexpressed in the epithelial cells of the transgenic mice. The mammary gland ductal trees were found to grow faster in MMTV-Kindlin-2 transgenic mice than in control mice during puberty. Kindlin-2 promoted mammary gland growth as indicated by more numerous duct branches and larger lumens, and more alveoli were formed in the mammary glands during pregnancy under Kindlin-2 overexpression. Importantly, mammary gland-specific expression of Kindlin-2 induced tumor formation at the age of 55 weeks on average. Additionally, the levels of estrogen receptor and progesterone receptor were decreased, whereas human epidermal growth factor receptor 2 and β-catenin were upregulated in the Kindlin-2-induced mammary tumors. These findings demonstrated that Kindlin-2 induces mammary tumor formation via activation of the Wnt signaling pathway.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85056845283&origin=inward; http://dx.doi.org/10.1007/s11427-018-9336-6; http://www.ncbi.nlm.nih.gov/pubmed/30460471; http://link.springer.com/10.1007/s11427-018-9336-6; http://sciencechina.cn/gw.jsp?action=cited_outline.jsp&type=1&id=6465511&internal_id=6465511&from=elsevier; https://dx.doi.org/10.1007/s11427-018-9336-6; https://link.springer.com/article/10.1007/s11427-018-9336-6
Springer Science and Business Media LLC
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