PlumX Metrics
Embed PlumX Metrics

Diabetes and depression

Diabetologe, ISSN: 1860-9724, Vol: 12, Issue: 5, Page: 346-351
2016
  • 1
    Citations
  • 0
    Usage
  • 12
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Background: One of four patients with type 2 diabetes mellitus (T2DM) has clinically relevant depression. On the other hand, depression increases the risk for T2DM as well as micro- and macrovascular complications. Objectives: This association may reflect a shared pathophysiology consisting of complex bidirectional interactions, which may influence therapy and prognosis. Materials and methods: Recent findings, reviews and basic literature are analysed and an update is presented and discussed. Results: Overall, accumulating evidence indicates a metabolic–mood syndrome with a linkage that includes stress sensitivity, insulin resistance (IR), neurohormonal dysregulation and inflammation. IR alters dopamine turnover and causes depression-like behaviour. Furthermore IR is associated with worse memory performance. Metabolic risk influences neurodevelopment. However, cross-sectional data do not support a genetic association between T2DM and depression. Conclusions: T2DM may promote depression and interact with neurodevelopment and neurodegeneration. Comorbidity seems to be particularly toxic. Both prevention of T2DM in depressed patients and treatment of depression in T2DM are of considerable significance. Serotonin reuptake inhibition (SSRI) and psychotherapy are effective in the treatment of depression.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know