DNA polymerase beta overexpression correlates with poor prognosis in esophageal cancer patients
Chinese Science Bulletin, ISSN: 1001-6538, Vol: 58, Issue: 26, Page: 3274-3279
2013
- 3Citations
- 6Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Gene of DNA polymerase beta (polβ) plays an important role in base excision repair, DNA replication and translesion synthesis. This study aims to investigate the expression and prognostic significance of DNA polβ in esophageal cancer. DNA polβ expression was analyzed using real-time quantitative PCR (RT-qPCR) and immunohistochemical staining on tissue samples from a consecutive series of 114 esophageal squamous carcinoma patients who underwent resections between 2002 and 2006. Polβ expression was investigated on its correlation to clinico-pathological factors and survival. RT-qPCR results showed higher expression of DNA polβ mRNA in tumor tissue than in its matched adjacent non-tumor tissue sample, different expression of DNA polβ mRNA was noticed with significance between tumors with and without lymph node metastasis. Immunohistochemistry staining results indicated the polβ strong-positive rate was 44.73% (51/114) in tumor tissue samples and 0.00% in matched adjacent non-tumor tissue samples, with significant difference. Kaplan-Meier survival curves revealed that high expression of pol? was associated with tumor metastasis and poor prognosis in esophageal cancer patients. Our data suggests that polβ plays an important role in tumor progression and that high polβ expression predicts an unfavorable prognosis in esophageal squamous carcinoma patients. © 2013 The Author(s).
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84883455988&origin=inward; http://dx.doi.org/10.1007/s11434-013-5956-2; http://link.springer.com/10.1007/s11434-013-5956-2; http://link.springer.com/content/pdf/10.1007/s11434-013-5956-2; https://dx.doi.org/10.1007/s11434-013-5956-2; https://link.springer.com/article/10.1007/s11434-013-5956-2
Springer Science and Business Media LLC
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know