HIV-1 Transgenic Female Rat: Synaptodendritic Alterations of Medium Spiny Neurons in the Nucleus Accumbens
Journal of Neuroimmune Pharmacology, ISSN: 1557-1904, Vol: 9, Issue: 5, Page: 642-653
2014
- 51Citations
- 15Captures
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Metrics Details
- Citations51
- Citation Indexes51
- 50
- CrossRef26
- Captures15
- Readers15
- 15
Article Description
HIV-1 associated neurocognitive deficits are increasing in prevalence, although the neuronal basis for these deficits is unclear. HIV-1 Tg rats constitutively express 7 of 9 HIV-associated proteins, and may be useful for studying the neuropathological substrates of HIV-1 associated neurocognitive disorders (HAND). In this study, adult female HIV-1 Tg rats and F344 control rats had similar growth rates, estrous cyclicity and startle reflex inhibition to a visual prepulse stimulus. Medium spiny neurons (MSNs) in the nucleus accumbens (NAcc) were ballistically-labeled utilizing the indocarbocyanine dye DiI. The branching complexity of MSNs in the NAcc was significantly decreased in HIV-1 Tg rats, relative to controls; moreover, the shorter length and decreased volume of dendritic spines, but unchanged head diameter, in HIV-1 Tg rats suggested a reduction of longer spines and an increase in shorter, less projected spines, indicating a population shift to a more immature spine phenotype. Collectively, these results from HIV-1 Tg female rats indicated significant synaptodendritic alterations of MSNs in the NAcc occur as a consequence of chronic, low-level, exposure to HIV-1 associated proteins.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84911002282&origin=inward; http://dx.doi.org/10.1007/s11481-014-9555-z; http://www.ncbi.nlm.nih.gov/pubmed/25037595; http://link.springer.com/10.1007/s11481-014-9555-z; https://dx.doi.org/10.1007/s11481-014-9555-z; https://link.springer.com/article/10.1007/s11481-014-9555-z
Springer Science and Business Media LLC
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