HPV-associated head and neck tumors: Update 2017
Best Practice Onkologie, ISSN: 1862-8559, Vol: 12, Issue: 3-4, Page: 130-136
2017
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Review Description
Squamous cell carcinomas of the head and neck (HNSCC) are the sixth most common cancers worldwide. Classical risk factors are alcohol and tobacco; however, for oropharyngeal carcinomas (OPC), human papillomavirus (HPV) infections have been identified as the most relevant pathogenetic drivers. The incidence of HPV-associated OPC is increasing in Europe, Japan, and the USA. HPV-derived oncoproteins E6 and E7 are key factors in the molecular pathogenesis of OPC. The prognosis of patients with HPV-associated OPC undergoing any kind of primary or secondary treatment modality (surgery, adjuvant or palliative chemo- or radiotherapy, molecular-targeted therapy, or immune checkpoint blockade) is more favorable than that of patients with HPV-negative HNSCC. The 2017 update of the Cancer Staging System of the American Joint Committee on Cancer now includes HPV-associated OPC as a distinct entity. According to updated evidence-based treatment guidelines, despite their more favorable prognosis, HPV-associated OPC patients should not be managed with less intensive treatment regimens (outside controlled clinical trials). HPV vaccination should be recommended to young men as well.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85032392719&origin=inward; http://dx.doi.org/10.1007/s11654-017-0023-0; http://link.springer.com/10.1007/s11654-017-0023-0; http://link.springer.com/content/pdf/10.1007/s11654-017-0023-0.pdf; http://link.springer.com/article/10.1007/s11654-017-0023-0/fulltext.html; https://dx.doi.org/10.1007/s11654-017-0023-0; https://link.springer.com/article/10.1007/s11654-017-0023-0
Springer Nature
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