Therapeutic Role of Chinese Medicine Targeting Nrf2/HO-1 Signaling Pathway in Myocardial Ischemia/Reperfusion Injury
Chinese Journal of Integrative Medicine, ISSN: 1993-0402, Vol: 30, Issue: 10, Page: 949-960
2024
- 2Citations
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Review Description
Acute myocardial infarction (AMI), characterized by high incidence and mortality rates, poses a significant public health threat. Reperfusion therapy, though the preferred treatment for AMI, often exacerbates cardiac damage, leading to myocardial ischemia/reperfusion injury (MI/RI). Consequently, the development of strategies to reduce MI/RI is an urgent priority in cardiovascular therapy. Chinese medicine, recognized for its multi-component, multi-pathway, and multi-target capabilities, provides a novel approach for alleviating MI/RI. A key area of interest is the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. This pathway is instrumental in regulating inflammatory responses, oxidative stress, apoptosis, endoplasmic reticulum stress, and ferroptosis in MI/RI. This paper presents a comprehensive overview of the Nrf2/HO-1 signaling pathway’s structure and its influence on MI/RI. Additionally, it reviews the latest research on leveraging Chinese medicine to modulate the Nrf2/HO-1 pathway in MI/RI treatment.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85184417310&origin=inward; http://dx.doi.org/10.1007/s11655-024-3657-0; http://www.ncbi.nlm.nih.gov/pubmed/38329655; https://link.springer.com/10.1007/s11655-024-3657-0; https://dx.doi.org/10.1007/s11655-024-3657-0; https://link.springer.com/article/10.1007/s11655-024-3657-0; http://sciencechina.cn/gw.jsp?action=cited_outline.jsp&type=1&id=7816928&internal_id=7816928&from=elsevier
Springer Science and Business Media LLC
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