A simple fluorescent pH probe and its application in cells
Chemical Papers, ISSN: 1336-9075, Vol: 73, Issue: 6, Page: 1481-1488
2019
- 13Citations
- 15Captures
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Article Description
It is very important to measure the pH in the cells because abnormal pH in the body can cause many neurological diseases. In this work, a simple emission fluorescent pH probe 2-(benzothiazol-2-yl)-1-((pyren-3-yl) methylene) hydrazine (BMH) was synthesized by connecting pyrene-1-carboxaldehyde and 2-hydrazinobenzothiazole. BMH displayed fluorescence emission characteristics in which the pK was 3.49 and responded linearly to measure pH range from 4.70 to 3.16. Meanwhile, it possessed high fluorescence quantum yield (64.60%). Moreover, BMH exhibited good stability and highly selectivity which promotes its ability in analytical application and the detection limit of approach was 0.41 μΜ. Simultaneously, it was fully able to image pH fluctuations due to its cell membrane permeability, biocompatibility and no auto-fluorescence effects.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85064899889&origin=inward; http://dx.doi.org/10.1007/s11696-019-00699-9; http://link.springer.com/10.1007/s11696-019-00699-9; http://link.springer.com/content/pdf/10.1007/s11696-019-00699-9.pdf; http://link.springer.com/article/10.1007/s11696-019-00699-9/fulltext.html; https://dx.doi.org/10.1007/s11696-019-00699-9; https://link.springer.com/article/10.1007/s11696-019-00699-9
Springer Science and Business Media LLC
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