Synthesis and study the loading and releasing of losartan potassium on the modified mesoporous silica
Chemical Papers, ISSN: 1336-9075, Vol: 76, Issue: 6, Page: 3949-3961
2022
- 2Citations
- 4Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
In this study, the mesoporous MCM-41 have been prepared and modified with acidic agents, including citric acid, acetic acid, and ascorbic acid to obtain a suitable drug carrier for the controlled release of losartan potassium. The prepared samples have been characterized by XRD, FTIR, SEM, TGA and BET methods. Then, the drug loading of losartan potassium on modified MCM-41 has been investigated for the first time. Subsequently, the effects of carrier type, carrier concentration, contact time, drug solution concentration and pH of the drug solution have been investigated, and the optimum loading conditions have been evaluated. The results of drug loading show that loading of losartan potassium in MCM-41 functionalized with citric acid and ascorbic acid is higher than other synthesized samples. The amount of losartan loaded in these carriers is 97.68 and 60.76%, respectively. Moreover, the results of the drug release phase experiments in the pH range of (3–11) show that the highest drug release is at pH = 7.4. Finally, five kinetic models are used to determine the rate of the drug release. Based on the kinetic modeling, it is found that the release of losartan potassium from MCM-41-Ci and MCM-41-As obeys the Higuchi model with non-Fickian diffusion. This was confirmed by investigating the results of error function analysis.
Bibliographic Details
Springer Science and Business Media LLC
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know