Coenzyme Q and statin myalgia: What is the evidence?
Current Atherosclerosis Reports, ISSN: 1523-3804, Vol: 12, Issue: 6, Page: 407-413
2010
- 39Citations
- 49Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations39
- Citation Indexes39
- 39
- CrossRef18
- Captures49
- Readers49
- 49
Review Description
Statins lower cholesterol by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in the biosynthesis of cholesterol. However, severe adverse events, including myalgias and rhabdomyolysis, have been reported with statin treatment. Different mechanisms have been proposed to explain statin-induced myopathy, including reduction of mevalonate pathway products, induction of apoptosis, mitochondrial dysfunction, and genetic predisposition. A decrease in coenzyme Q (CoQ), a product of the mevalonate pathway, could contribute to statin induced myopathy. This article reviews the clinical and biochemical features of statin-induced myopathy, the inter-relationship between statins and the concentration of CoQ in plasma and tissues, and whether there is a role for supplementation with CoQ to attenuate statin-induced myopathy. © 2010 Springer Science+Business Media, LLC.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77958196854&origin=inward; http://dx.doi.org/10.1007/s11883-010-0134-3; http://www.ncbi.nlm.nih.gov/pubmed/20725809; http://link.springer.com/10.1007/s11883-010-0134-3; http://www.springerlink.com/index/10.1007/s11883-010-0134-3; http://www.springerlink.com/index/pdf/10.1007/s11883-010-0134-3; https://dx.doi.org/10.1007/s11883-010-0134-3; https://link.springer.com/article/10.1007/s11883-010-0134-3; https://research-repository.uwa.edu.au/en/publications/coenzyme-q10-and-statin-myalgia-what-is-the-evidence(2cf7746b-32d6-48d2-b016-a4e45c23bc86).html; https://research-repository.uwa.edu.au/en/publications/coenzyme-q10-and-statin-myalgia-what-is-the-evidence; https://research-repository.uwa.edu.au/en/publications/2cf7746b-32d6-48d2-b016-a4e45c23bc86; https://link.springer.com/content/pdf/10.1007%2Fs11883-010-0134-3.pdf; http://link.springer.com/article/10.1007%2Fs11883-010-0134-3; http://research-repository.uwa.edu.au/en/publications/coenzyme-q10-and-statin-myalgia-what-is-the-evidence(2cf7746b-32d6-48d2-b016-a4e45c23bc86).html
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