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The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update

Current Diabetes Reports, ISSN: 1539-0829, Vol: 18, Issue: 12, Page: 136
2018
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Review Description

Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. Summary: TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D.

Bibliographic Details

Marian Rewers; Heikki Hyöty; Åke Lernmark; William Hagopian; Jin Xiong She; Desmond Schatz; Pittman G. Ziegler; Jorma Toppari; Beena Akolkar; Jeffrey Krischer; Kimberly Bautista; Judith Baxter; Daniel Felipe-Morales; Kimberly Driscoll; Brigitte I. Frohnert; Marisa Gallant; Patricia Gesualdo; Michelle Hoffman; Rachel Karban; Edwin Liu; Jill Norris; Adela Samper-Imaz; Andrea Steck; Kathleen Waugh; Hali Wright; Olli G. Simell; Annika Adamsson; Suvi Ahonen; Jorma Ilonen; Sanna Jokipuu; Leena Karlsson; Miia Kähönenμ; Mikael Knip; Mirva Koreasalo; Kalle Kurppa; Tiina Latva-ahoμ; Maria Lönnrot; Markus Mattila; Elina Mäntymäki; Katja Multasuoμ; Tiina Niininen; Sari Niinistö; Mia Nyblom; Sami Oikarinen; Paula Ollikainenμ; Petra Rajala; Jenna Rautanen; Anne Riikonen; Minna Romo; Suvi Ruohonen; Juulia Rönkäμ; Satu Simell; Tuula Simell; Maija Sjöberg; Aino Steniusμ; Sini Vainionpää; Eeva Varjonen; Riitta Veijola; Suvi M. Virtanen; Mari Vähä-Mäkilä; Mari Åkerlund; Katri Lindfors; Diane Hopkins; Leigh Steed; Jennifer Bryant; Janey Adams; Katherine Silvis; Michael Haller; Melissa Gardiner; Richard McIndoe; Ashok Sharma; Stephen W. Anderson; Laura Jacobsen; John Marks; Andreas Beyerlein; Ezio Bonifacio; Anita Gavrisan; Cigdem Gezginci; Anja Heublein; Michael Hummel; Sandra Hummel; Andrea Keimer; Annette Knopff; Charlotte Koch; Sibylle Koletzko; Claudia Ramminger; Roswith Roth; Marlon Scholz; Joanna Stock; Katharina Warncke; Lorena Wendel; Christiane Winkler; Daniel Agardh; Carin Andrén Aronsson; Maria Ask; Jenny Bremer; Ulla Marie Carlsson; Corrado Cilio; Emelie Ericson-Hallström; Annika Fors; Lina Fransson; Thomas Gard; Rasmus Bennet; Carina Hansson; Susanne Hyberg; Hanna Jisser; Fredrik Johansen; Berglind Jonsdottir; Silvija Jovic; Helena Elding Larsson; Marielle Lindström; Markus Lundgren; Maria Månsson-Martinez; Maria Markan; Jessica Melin; Zeliha Mestan; Caroline Nilsson; Karin Ottosson; Kobra Rahmati; Anita Ramelius; Falastin Salami; Sara Sibthorpe; Anette Sjöberg; Birgitta Sjöberg; Carina Törn; Anne Wallin; Åsa Wimar; Sofie Åberg; William A. Hagopian; Michael Killian; Claire Cowen Crouch; Jennifer Skidmore; Ashley Akramoff; Jana Banjanin; Masumeh Chavoshi; Kayleen Dunson; Rachel Hervey; Rachel Lyons; Arlene Meyer; Denise Mulenga; Jared Radtke; Davey Schmitt; Julie Schwabe; Sarah Zink; Dorothy Becker; Margaret Franciscus; Mary Ellen Dalmagro Elias Smith; Ashi Daftary; Mary Beth Klein; Chrystal Yates; Jeffrey P. Krischer; Sarah Austin-Gonzalez; Maryouri Avendano; Sandra Baethke; Rasheedah Brown; Brant Burkhardt; Martha Butterworth; Joanna Clasen; David Cuthbertson; Christopher Eberhard; Steven Fiske; Dena Garcia; Jennifer Garmeson; Veena Gowda; Kathleen Heyman; Belinda Hsiao; Francisco Perez Laras; Hye Seung Lee; Shu Liu; Xiang Liu; Kristian Lynch; Colleen Maguire; Jamie Malloy; Cristina McCarthy; Aubrie Merrell; Steven Meulemans; Hemang Parikh; Ryan Quigley; Cassandra Remedios; Chris Shaffer; Laura Smith; Susan Smith; Noah Sulman; Roy Tamura; Ulla Uusitalo; Kendra Vehik; Ponni Vijayakandipan; Keith Wood; Jimin Yang; Michael Abbondondolo; Lori Ballard; David Hadley; Wendy McLeod; Kasia Bourcier; Thomas Briese; Suzanne Bennett Johnson; Eric Triplett; Liping Yu; Dongmei Miao; Polly Bingley; Alistair Williams; Kyla Chandler; Olivia Ball; Ilana Kelland; Sian Grace; Ben Gillard; Elisabeth Aardal Eriksson; Ing Marie Lundgren; Ewa Lönn Karlsson; Dzeneta Nezirevic Dernroth; Iris Erlund; Irma Salminen; Jouko Sundvall; Nina Kangas; Petra Arohonka; Randie R. Little; Curt Rohlfing; Henry Erlich; Steven J. Mack; Anna Lisa Fear; Oliver Fiehn; Bill Wikoff; Brian Defelice; Dmitry Grapov; Tobias Kind; Mine Palazoglu; Luis Valdiviez; Benjamin Wancewicz; Gert Wohlgemuth; Joyce Wong; Joseph F. Petrosino; Nadim J. Ajami; Richard E. Lloyd; Matthew C. Ross; Jacqueline L. O’Brien; Diane S. Hutchinson; Daniel P. Smith; Matthew C. Wong; Xianjun Tian; Tulin Ayvaz; Auriole Tamegnon; Nguyen Truong; Hannah Moreno; Lauren Riley; Eduardo Moreno; Tonya Bauch; Lenka Kusic; Ginger Metcalf; Donna Muzny; Harsha VArdhan Doddapaneni; Richard Gibbs; Santica M. Marcovina; Vinod P. Gaur; Richard D. Smith; Thomas O. Metz; Charles Ansong; Bobbie Jo Webb-Robertson; Hugh D. Mitchell; Ernesto S. Nakayasu; Wei Jun Qian; Sandra Ke; Niveen Mulholland; Haitao Liu; John Nechtman; Yansheng Zhao; Na Jiang; Yanna Tian; Guangkuo Dong; Stephen S. Rich; Wei Min Chen; Suna Onengut-Gumuscu; Emily Farber; Rebecca Roche Pickin; Jonathan Davis; Jordan Davis; Dan Gallo; Jessica Bonnie; Paul Campolieto; William E. Winter; David L. Pittman

Springer Science and Business Media LLC

Medicine

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