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HBsAg seroclearance in the natural history of chronic hepatitis B infection

Current Hepatitis Reports, ISSN: 1540-3416, Vol: 5, Issue: 1, Page: 23-26
2006
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Metric Options:   Counts1 Year3 Year

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Review Description

Hepatitis B surface antigen (HBsAg) seroclearance is a rare event that occurs in 0.1% to 2% of patients with chronic hepatitis B per year. Patients with HBsAg seroclearance have improvement of liver biochemistry and hepatic necroinflammation. The viral load gradually decreases with time, although some patients still have detectable intrahepatic hepatitis B virus DNA, mainly in the form of covalently closed circular DNA. There is no reduction of the risk of cirrhosis-related complications and hepatocellular carcinoma if HBsAg seroclearance occurs at an older age when cirrhosis has already been established. Copyright © 2006 by Current Science Inc.

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