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DILI Associated with Skin Reactions

Current Hepatology Reports, ISSN: 2195-9595, Vol: 17, Issue: 3, Page: 225-234
2018
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Article Description

Purpose of Review: Adverse drug reactions (ADR) frequently involve the liver and skin in the form of drug-induced liver injury or cutaneous drug eruption. Recent Findings: Skin ADR can range from harmless rash to severe skin manifestations such as drug rash with eosinophilia and systemic symptom syndrome (DRESS syndrome), Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP), all of which can be associated with severe outcome, including a 30% mortality rate in case of TEN. The association with co-occurring liver injury varies and in DRESS and SJS/TEN can contribute to substantial morbidity and mortality. Summary: Liver and skin ADR are frequent but rarely severe; however, if severe, they are not uncommonly fatal.

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