The skeletal subsystem as an integrative physiology paradigm
Current Osteoporosis Reports, ISSN: 1544-1873, Vol: 8, Issue: 4, Page: 168-177
2010
- 11Citations
- 17Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations11
- Citation Indexes11
- 11
- CrossRef10
- Captures17
- Readers17
- 17
Review Description
Homeostatic bone remodeling depends on precise regulation of osteoblast-osteoclast coupling through intricate endocrine, immune, neuronal, and mechanical factors. The osteoblast-osteoclast model of bone physiology with layers of regulatory complexity can be investigated as a component of a local skeletal subsystem or as a part of a complete whole-body system. In this review, we flip the traditional investigative paradigm of scientific experimentation ("bottom-top research") to a "top-bottom" approach using systems biology. We first establish the intricacies of the two-cell model at the molecular signaling level. We then provide, on a systems level, an integrative physiologic approach involving many recognized organ-level subsystems having direct and/or indirect effects on bone remodeling. Lastly, a hypothetical model of bone remodeling based on frequency and amplitude regulatory mechanisms is presented. It is hoped that by providing a thorough model of skeletal homeostasis, future progress can be made in researching and treating skeletal morbidities. © 2010 Springer Science+Business Media, LLC.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77958092410&origin=inward; http://dx.doi.org/10.1007/s11914-010-0033-0; http://www.ncbi.nlm.nih.gov/pubmed/20814769; http://link.springer.com/10.1007/s11914-010-0033-0; https://dx.doi.org/10.1007/s11914-010-0033-0; https://link.springer.com/article/10.1007/s11914-010-0033-0; http://www.springerlink.com/index/10.1007/s11914-010-0033-0; http://www.springerlink.com/index/pdf/10.1007/s11914-010-0033-0
Springer Science and Business Media LLC
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