2-Hexadecenal Regulates ROS Production and Induces Apoptosis in Polymorphonuclear Leucocytes
Cell Biochemistry and Biophysics, ISSN: 1559-0283, Vol: 81, Issue: 1, Page: 77-86
2023
- 7Citations
- 2Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations7
- Citation Indexes7
- Captures2
- Readers2
Article Description
2-Hexadecenal (2-HD)—a biologically active long-chain fatty aldehyde formed in organism enzymatically or nonenzymatically in the reaction of free-radical destruction of sphingolipids under the action of hypochlorous acid, producing by myeloperoxidase. This research aimed to study 2-HD effects on polymorphonuclear leukocytes’ (PMNLs) functions. It has been shown that at submicromolar concentrations, 2-HD causes an elevation in ROS production by PMNLs. It has been found that such effect is associated with signal transduction pathways modification and expressed in elevation of NADPH oxidase, MPO, and JNK-MAPK contributions to this process. At higher concentrations, 2-HD induces apoptosis, which correlates with a significant increase in free Ca in the cytoplasm, a decrease in ROS production, and a decline in mitochondrial potential. Both of these processes are accompanied by cytoskeleton reorganization.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85142455702&origin=inward; http://dx.doi.org/10.1007/s12013-022-01117-w; http://www.ncbi.nlm.nih.gov/pubmed/36418741; https://link.springer.com/10.1007/s12013-022-01117-w; https://dx.doi.org/10.1007/s12013-022-01117-w; https://link.springer.com/article/10.1007/s12013-022-01117-w
Springer Science and Business Media LLC
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