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The effect of vitamin D3 supplementation on markers of cardiovascular health in hyperparathyroid, vitamin D insufficient women: a randomized placebo-controlled trial

Endocrine, ISSN: 1559-0100, Vol: 62, Issue: 1, Page: 182-194
2018
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Article Description

Purpose: Emerging data supports an association between parathyroid hormone (PTH) and aldosterone. It has been speculated, that potential adverse cardiovascular effects of vitamin D insufficiency may partly be caused by the development of secondary hyperparathyroidism with increased activity of the renin-angiotensin-aldosterone system (RAAS). We aimed to investigate the effect of normalizing vitamin D status and/or reducing PTH levels on RAAS activity and other markers of cardiovascular health. Methods: In a double-blinded study during wintertime, we randomized 81 healthy postmenopausal women with secondary hyperparathyroidism (PTH > 6.9 pmol/l) and 25-hydroxy-vitamin D (25(OH)D) levels < 50 nmol/l to 12 weeks of treatment with vitamin D3 70 µg/day (2800 IU/day) or identical placebo. Markers of cardiovascular health were defined as changes in the plasma RAAS, glycated hemoglobin, lipids, and lipoproteins, blood pressure, vascular stiffness, heart rate, and cardiac conductivity. Results: Compared to placebo, vitamin D3 treatment significantly increased plasma levels of 25(OH)D and 1,25(OH)D by 230% (95% CI: 189–272%) and 58% (190–271%), respectively. Vitamin D3 treatment reduced PTH by 17% (11–23%), but did not reduce RAAS activity. Compared to placebo, vitamin D3 treatment increased plasma levels of high-density lipoproteins (HDL) by 4.6% (0.12–9.12%), but did not affect other measured indices. Conclusions: Vitamin D3 supplementation normalized vitamin D levels and reduced PTH. The supplement increased levels of HDL, but had no effects on RAAS activity or other indices of cardiovascular health.

Bibliographic Details

Bislev, Lise Sofie; Langagergaard Rødbro, Lene; Bech, Jesper Nørgaard; Pedersen, Erling Bjerregaard; Kjaergaard, Alisa D.; Ladefoged, Søren Andreas; Rolighed, Lars; Sikjaer, Tanja; Rejnmark, Lars

Springer Science and Business Media LLC

Medicine; Biochemistry, Genetics and Molecular Biology

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