Middle Ear “Adenoma”: a Neuroendocrine Tumor with Predominant L Cell Differentiation
Endocrine Pathology, ISSN: 1559-0097, Vol: 32, Issue: 4, Page: 433-441
2021
- 22Citations
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations22
- Citation Indexes22
- 22
- CrossRef11
- Captures12
- Readers12
- 12
Article Description
This morphological and immunohistochemical study demonstrates that tumors currently known as “middle ear adenomas” are truly well-differentiated epithelial neuroendocrine tumors (NETs) composed of cells comparable to normal intestinal L cells, and therefore, these tumors resemble hindgut NETs. These tumors show consistent expression of glucagon, pancreatic polypeptide, PYY, and the transcription factor SATB2, as well as generic neuroendocrine markers and keratins. The same L cell markers are expressed by cells within the normal middle ear epithelium. These markers define a valuable immunohistochemical profile that can be used for differential diagnosis of middle ear neoplasms, particularly in distinguishing epithelial NETs from paragangliomas. The discovery of neuroendocrine cells expressing the same markers in non-neoplastic middle ear mucosa opens new areas of investigation into the physiology of the normal middle ear and the pathophysiology of middle ear disorders.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85106455108&origin=inward; http://dx.doi.org/10.1007/s12022-021-09684-z; http://www.ncbi.nlm.nih.gov/pubmed/34041698; https://link.springer.com/10.1007/s12022-021-09684-z; https://dx.doi.org/10.1007/s12022-021-09684-z; https://link.springer.com/article/10.1007/s12022-021-09684-z
Springer Science and Business Media LLC
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