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Shifting Paradigm in the Management of Anal Canal Carcinoma

Journal of Gastrointestinal Cancer, ISSN: 1941-6636, Vol: 46, Issue: 1, Page: 1-4
2015
  • 5
    Citations
  • 0
    Usage
  • 7
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

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Review Description

Background: Anal canal is the lower most part of the gastrointestinal tract harbouring 4 % of all gastrointestinal cancer. Most common treatment for anal canal carcinoma includes chemoradiotherapy. Methodology: We reviewed the recent landmark trials to find a road map in the management of anal canal carcinoma. Results: Concurrent chemoradiotherapy appears to be the most effective treatment schedule. Induction, as well as maintenance chemotherapy, has no definite role. Moderate dose radiation 50.4–54 Gy with concurrent mitomycin C (MMC) and 5-fluorouracil (5-FU) remains the standard. Split course is detrimental. Intensity-modulated radiotherapy and targeted drugs are investigated. Conclusion: Combined modality therapy is the standard for anal canal carcinoma.

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