Neuroprotective Effect of Biatractylenolide Against Memory Impairment in d-Galactose-induced Aging Mice
Journal of Molecular Neuroscience, ISSN: 1559-1166, Vol: 55, Issue: 3, Page: 678-683
2015
- 23Citations
- 19Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations23
- Citation Indexes23
- 23
- CrossRef8
- Captures19
- Readers19
- 19
Article Description
Biatractylenolide, a sesquiterpene lactone, which exerted the neuroprotective effect against glutamate-induced excitotoxicity, was isolated from Atractylodis macrocephala in our previous study. In this study, we evaluated the neuroprotective effect of biatractylenolide against d-galactose-induced memory impairment and explored the potential mechanism of its action. The results showed that administration of biatractylenolide could significantly improve behavioral performance of d-galactose-treated mice in passive avoidance test and spatial learning-memory test. Administration of biatractylenolide could significantly decrease the formation of reactive oxygen species (ROS), decrease the activity of acetylcholinesterase (AChE), and increase the expression of synapsin I and protein kinase C (PKC) in d-galactose-treated mice. Our findings provide first evidence for the neuroprotective effect of biatractylenolide against d-galactose-induced memory impairment. The potential mechanisms underlying the neuroprotective effect of biatractylenolide in d-galactose-treated mice might be (i) attenuating oxidative damage via decreasing ROS formation, (ii) restoring cholinergic neurotransmission via decreasing AChE activity, and (iii) increasing the expression of memory-related proteins (synapsin I and PKC). Biatractylenolide may have therapeutic potential in aging-related memory impairment.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84922225316&origin=inward; http://dx.doi.org/10.1007/s12031-014-0407-3; http://www.ncbi.nlm.nih.gov/pubmed/25173400; http://link.springer.com/10.1007/s12031-014-0407-3; https://dx.doi.org/10.1007/s12031-014-0407-3; https://link.springer.com/article/10.1007/s12031-014-0407-3
Springer Science and Business Media LLC
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