PlumX Metrics
Embed PlumX Metrics

Dysregulated miRNAs in Progression and Pathogenesis of Alzheimer’s Disease

Molecular Neurobiology, ISSN: 1559-1182, Vol: 59, Issue: 10, Page: 6107-6124
2022
  • 18
    Citations
  • 0
    Usage
  • 28
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Most Recent News

Dysregulated miRNAs in Progression and Pathogenesis of Alzheimer's Disease.

Mol Neurobiol. 2022 Jul 22; Authors: Arora T, Prashar V, Singh R, Barwal TS, Changotra H, Sharma A, Parkash J PubMed: 35867206 Submit Comment

Review Description

Alzheimer’s disease (AD) is a progressive degeneration of neurons due to the accumulation of amyloid-β peptide (Aβ) and hyper-phosphorylation of tau protein in the neuronal milieu leading to increased oxidative stress and apoptosis. Numerous factors contribute towards the progression of AD, including miRNA, which are 22–24 nucleotides long sequence which acts as critical regulators of cellular processes by binding to 3′ UTR of mRNA, regulating its expression post-transcriptionally. This review aims to determine the miRNA with the most significant dysregulation in the brain and cerebrospinal fluid (CSF) of human patients. A systemized inclusion/exclusion criterion has been utilized based on selected keywords followed by screening of those articles to conclude a list of 8 highly dysregulated miRNAs based on the fold change of AD vs control patients, which could be used in clinical testing as these miRNAs play central role in the pathophysiology of AD. Furthermore, a network study of highly dysregulated miRNA estimated the association of these miRNA in the mediation of Aβ generation and aggregation, inhibition of autophagy, reduction of Aβ clearance, microglial and astrocytic activation, neuro-inflammation, tau hyper-phosphorylation, and synaptic loss.

Bibliographic Details

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know