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Backbone resonance assignments of the PRYSPRY domain of TRIM25

Biomolecular NMR Assignments, ISSN: 1874-270X, Vol: 9, Issue: 2, Page: 313-315
2015
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Article Description

TRIM25 is a member of the tripartite motif (TRIM) family and has been implicated in the regulation of innate immune signaling via the RIG-I (retinoic acid-inducible gene-I) pathway for antiviral defense. As the essential first step towards the structural and functional characterization of the TRIM25/RIG-I interaction, the backbone resonance of the PRYSPRY domain of TRIM25 is assigned here based on triple-resonance experiments using uniformly [H, C, N]-labeled protein.

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