SGLT-2i: Nanoparticular-Based Strategies, Solutions, and Clinical Applications in Opposition to Low Bioavailability

Purpose: Although SGLT-2i initially acquired prominence for usage in diabetes, they later emerged as the top medication class in both cardiovascular diseases and disorders. However, they still do not have the proper bioavailability (50–70%); therefore, it has different options such as using either a higher dose amount or dose frequency. Methods: The aim of this review is focusing on current trials of SGLT-2i with less side effects and improved patient compliance, which lead to different options such as using either a higher dose amount or dose frequency. Results: With the acceleration of clinical studies, it would not be surprising to witness the introduction of SGLT-2i nano-based systems as a commercial product in the upcoming years. Conclusion: Research on SGLT-2i-based systems is being conducted to facilitate the development of new drug delivery methods such as microemulsion and self-nanoemulsifying drug delivery system. Graphical Abstract: [Figure not available: see fulltext.].