The Gab2 in signal transduction and its potential role in the pathogenesis of Alzheimer's disease
Neuroscience Bulletin, ISSN: 1673-7067, Vol: 26, Issue: 3, Page: 241-246
2010
- 24Citations
- 26Captures
- 1Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations24
- Citation Indexes24
- 24
- CrossRef15
- Captures26
- Readers26
- 26
- Mentions1
- References1
- Wikipedia1
Article Description
The growth factor receptor-bound protein 2 (Grb2)-associated binder (Gab) proteins are intracellular scaffolding/ docking molecules, and participate in multiple signaling pathways, usually acting as the downstream effector of proteintyrosine kinases (PTKs)-triggered signal transduction pathway. When phosphorylated by PTKs, Gab proteins can recruit several signaling molecules (p85, SHP2, and Crk), and subsequently activate multiple transmitting signals that are critical for cell growth, survival, differentiation and apoptosis. Recently, it has been reported that Gab2 polymorphism is associated with the increase in the risk of Alzheimer's disease (AD) and is involved in the pathogenesis of AD. This review mainly focuses on the structure and function of Gab2 protein and its role in the pathogenesis of AD. © 2010 Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77955972241&origin=inward; http://dx.doi.org/10.1007/s12264-010-1109-7; http://www.ncbi.nlm.nih.gov/pubmed/20502503; http://link.springer.com/10.1007/s12264-010-1109-7; https://dx.doi.org/10.1007/s12264-010-1109-7; https://link.springer.com/article/10.1007/s12264-010-1109-7; http://www.springerlink.com/index/10.1007/s12264-010-1109-7; http://www.springerlink.com/index/pdf/10.1007/s12264-010-1109-7
Springer Science and Business Media LLC
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