Investigation of the relationship between in vitro and in vivo release behaviors of acamprosate from enteric-coated tablets
Archives of Pharmacal Research, ISSN: 0253-6269, Vol: 31, Issue: 6, Page: 798-804
2008
- 8Citations
- 14Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef2
- Captures14
- Readers14
- 14
Article Description
Acamprosate calcium is a highly soluble drug with low permeability that is used to maintain abstinence in alcohol-dependent patients. The aim of this study was to investigate the relationship between in vitro and in vivo behaviors of acamprosate from enteric-coated tablets. The in vitro release behavior of acamprosate tablets in pH 6.8 buffer solution was determined in three dissolution conditions, 50 and 150 rpm (paddle method) and 180 rpm (basket method). The results of this in vitro experiment indicated that acamprosate tablets hardly disintegrated, and drug dissolution was retarded despite the extremely hydrophilic nature of the drug. A single dose (333 mg×2 tablets) of each formulation was orally administered to four beagle dogs under fasting conditions, and the pharmacokinetic parameters were calculated. The mean AUC, C, T and T for the two types of tablets ranged from 41.5-53.6 μg·h/mL, 4.3-4.5 μg/mL, 2.0-2.5 h and 3.8-4.0 h, respectively. In conclusion, it is suggested that retarded drug release from the tablets and the low drug permeability may result in poor absorption and erratic bioavailability of this drug in humans. © 2008 The Pharmaceutical Society of Korea.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=45749154238&origin=inward; http://dx.doi.org/10.1007/s12272-001-1229-y; http://www.ncbi.nlm.nih.gov/pubmed/18563364; http://link.springer.com/10.1007/s12272-001-1229-y; https://dx.doi.org/10.1007/s12272-001-1229-y; https://link.springer.com/article/10.1007/s12272-001-1229-y; http://www.springerlink.com/index/10.1007/s12272-001-1229-y; http://www.springerlink.com/index/pdf/10.1007/s12272-001-1229-y
Springer Science and Business Media LLC
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