Triterpenoid saponins from Clinopodium chinense (Benth.) O. Kuntze and their biological activity
Archives of Pharmacal Research, ISSN: 1976-3786, Vol: 41, Issue: 12, Page: 1117-1130
2018
- 15Citations
- 15Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations15
- Citation Indexes15
- 15
- CrossRef1
- Captures15
- Readers15
- 15
Article Description
Four new ursane-type triterpenoid saponins, clinopoursaponins A–D (1–4), six new oleanane-type triterpenoid saponins, clinopodiside VII–XII (5–10), as well as eight known triterpene analogues (11–18), were isolated from the aerial parts of Clinopodium chinense (Benth.) O. Kuntze. The structures of the new compounds were determined based on extensive spectral analyses, including 1D (H and C) and 2D NMR experiments (COSY, NOESY, HSQC, 2D TOCSY, HSQC-TOCSY and HMBC), HR-ESI-MS and chemical methods. Compounds 1–18 were evaluated for their protective effects against anoxia/reoxygenation-induced apoptosis in H9c2 cells and cytotoxicities against murine mammary carcinoma cell line 4T1. Compounds 8, 9 and 18 exhibited significant protective effects, while compound 1 exhibited cytotoxic activity with IC value of 7.4 μm compared to 7.6 μm for the positive control 10-hydroxycamptothecin.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85029041564&origin=inward; http://dx.doi.org/10.1007/s12272-017-0943-9; http://www.ncbi.nlm.nih.gov/pubmed/28895057; http://link.springer.com/10.1007/s12272-017-0943-9; https://dx.doi.org/10.1007/s12272-017-0943-9; https://link.springer.com/article/10.1007/s12272-017-0943-9
Springer Nature
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