Anti-inflammatory activity of caffeic acid derivatives isolated from the roots of Salvia miltiorrhiza Bunge
Archives of Pharmacal Research, ISSN: 1976-3786, Vol: 41, Issue: 1, Page: 64-70
2018
- 70Citations
- 71Captures
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Metrics Details
- Citations70
- Citation Indexes70
- 70
- CrossRef14
- Captures71
- Readers71
- 71
Article Description
Ten caffeic acid derivatives (1–10) were isolated from the roots of Salvia miltiorrhiza by using various chromatographic methods and their chemical structures were spectroscopically elucidated. The absolute configurations of chiral centers were determined by comparison with reported coupling constants, optical rotation values, and CD techniques. Anti-inflammatory activities were evaluated using nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 inhibition assays, and by determining the expression of heme oxygenase (HO)-1. Two new caffeic acid derivatives, 8-epiblechnic acid 9-methyl ester (4) and 8-epiblechnic acid 9′-methyl ester (5), and eight known derivatives, caffeic acid methyl ester (1), shimobashiric acid B (2), rosmarinic acid methyl ester (3), salvianolic acid C (6), methyl salvianolate C (7), lithospermic acid monomethyl ester (8), lithospermic acid dimethyl ester (9), and dimethyl lithospermate B (10), were isolated from the ethyl acetate fraction of S. miltiorrhiza. All caffeic acid derivatives were evaluated for their inhibitory effect on NO production. Compounds 2 and 3 inhibited NO production with IC values of 1.4 and 0.6 μM, respectively. These compounds also strongly inhibited the production of iNOS and COX-2. In addition, compound 3 induced the expression HO-1 in a concentration-dependent manner at 0.1, 0.3, and 1.0 μM.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85033476869&origin=inward; http://dx.doi.org/10.1007/s12272-017-0983-1; http://www.ncbi.nlm.nih.gov/pubmed/29124660; http://link.springer.com/10.1007/s12272-017-0983-1; https://dx.doi.org/10.1007/s12272-017-0983-1; https://link.springer.com/article/10.1007/s12272-017-0983-1
Springer Science and Business Media LLC
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