Determination of serum aflatoxin B-lysine to evaluate the efficacy of an aflatoxin-adsorbing feed additive in pigs fed an aflatoxin B-contaminated diet
Mycotoxin Research, ISSN: 1867-1632, Vol: 33, Issue: 2, Page: 93-102
2017
- 10Citations
- 39Captures
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Metrics Details
- Citations10
- Citation Indexes10
- 10
- CrossRef6
- Captures39
- Readers39
- 39
Article Description
In this study, serum aflatoxin B (AFB)-lysine was determined in order to evaluate the in vivo efficacy of a hydrated sodium calcium aluminosilicate (HSCAS) in pigs fed AFB. Twenty-four 49-day-old crossbred barrows were maintained in individual cages and allowed ad libitum access to feed and water. A completely randomized design was used with six animals assigned to each of four dietary treatments for 21 days as follows: (A) basal diet (BD), (B) BD supplemented with 0.5 % HSCAS, (C) BD supplemented with 1.1 mg/kg AFB, and (D) BD supplemented with 0.5 % HSCAS and 1.1 mg/kg AFB. HSCAS was able to alleviate the toxic effects of AFB on pigs and reduce (P < 0.05) the levels of serum AFB-lysine. Cumulative reductions of adduct yield values, calculated through the equation [(pg AFB-lysine/mg albumin) / (μg AFB/kg body weight)], were 53.0, 62.8, and 72.1 after 7, 14, and 21 days of oral exposure, respectively. AFB-lysine has potential as an AFB-specific biomarker for diagnostic purposes and for evaluating the efficacy of chemoprotective interventions in pigs.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85007427018&origin=inward; http://dx.doi.org/10.1007/s12550-016-0267-5; http://www.ncbi.nlm.nih.gov/pubmed/28035652; http://link.springer.com/10.1007/s12550-016-0267-5; https://dx.doi.org/10.1007/s12550-016-0267-5; https://link.springer.com/article/10.1007/s12550-016-0267-5
Springer Science and Business Media LLC
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