Modulators reducing the efficiency of oxidative ATP synthesis in mitochondria: protonophore uncouplers, cyclic redox agents, and decouplers
Biophysical Reviews, ISSN: 1867-2469, Vol: 15, Issue: 5, Page: 851-857
2023
- 1Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations1
- Citation Indexes1
- CrossRef1
- Captures3
- Readers3
Review Description
This work considers the main indicators of the oxidative phosphorylation efficiency in mitochondria: the ADP/O and H/O ratios. Three groups of modulators that reduce the efficiency of oxidative phosphorylation are compared: protonophore uncouplers, cyclic redox compounds, and decouplers. It is noted that some of them are considered effective therapeutic agents. The paper analyzes the authors’ original data on the mechanism of action of natural decouplers, represented by long-chain α,ω-dioic acids, as antioxidants. In conclusion, we discuss the hypothesis of their participation in the rescue of hepatocytes in various disorders of carbohydrate and lipid metabolism.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85173101254&origin=inward; http://dx.doi.org/10.1007/s12551-023-01160-8; http://www.ncbi.nlm.nih.gov/pubmed/37974985; https://link.springer.com/10.1007/s12551-023-01160-8; https://dx.doi.org/10.1007/s12551-023-01160-8; https://link.springer.com/article/10.1007/s12551-023-01160-8
Springer Science and Business Media LLC
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