Effect of GDNF on Morphology, Proliferation, and Phagocytic Activity of Rat Neonatal Cortex Isolated Microglia
BioNanoScience, ISSN: 2191-1649, Vol: 6, Issue: 4, Page: 379-383
2016
- 3Citations
- 7Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Microglia are the main defenders of the central nervous system and at the same time are involved in the pathogenesis of various neurological disorders. Microglia hyperactivity or phagocytic impairment exacerbates degenerative processes in nervous tissue leading to further loss of function. A variety of factors and cytokines may modify microglia function. In our study, it was shown that glial cell line-derived neurotrophic factor (GDNF), a well-known neuroprotective molecule, decreases phagocytic activity of microglia in vitro model of spinal cord injury. Recombinant adenovirus encoding GDNF (Ad5-GDNF) transfected microglia have shown the same effect and can be potentially used as a therapeutic agent in case of neurotrauma due to its debris phagocytic and GDNF-associated neuroprotective role.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84999861873&origin=inward; http://dx.doi.org/10.1007/s12668-016-0247-4; http://link.springer.com/10.1007/s12668-016-0247-4; http://link.springer.com/content/pdf/10.1007/s12668-016-0247-4.pdf; http://link.springer.com/article/10.1007/s12668-016-0247-4/fulltext.html; https://dx.doi.org/10.1007/s12668-016-0247-4; https://link.springer.com/article/10.1007/s12668-016-0247-4
Springer Science and Business Media LLC
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