Preparation of multifunctional polymeric micelles for antiviral treatment
Macromolecular Research, ISSN: 1598-5032, Vol: 18, Issue: 8, Page: 747-752
2010
- 13Citations
- 22Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
In this study, a poly(L-lactic acid)-Z-b-poly(ethylene glycol) (PLLA-b-PEG) diblock copolymer modified with a sialic acid derivative (methyl-b-neuraminic acid: mNA) was prepared for the development and application of a therapeutic nanosystem with multifunctionality. The terminal carboxyl group of PEG was coupled with mNA via N,N'-dicyclohexyl carbodiimide (DCC)-and N-hydroxysuccinimide (NHS)-mediated amide formation. Polymeric micelles were formed using the diafilteration method at pH 7.4, which resulted in a micelle self-assembly with the PLLA block at the core and PEG-mNA block on the shell. An anionic charge was formed on the surface of the micelle at physiological pH (∼pH 7.4) due to mNA. Amantadine (AMT), a model drug for antiviral treatment, was loaded into the micellar core. These micelles were expected to exhibit multiple therapeutic activity that originated from the antiviral activity of mNA on the shell and the sustained release of AMT from the micellar core.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78149302847&origin=inward; http://dx.doi.org/10.1007/s13233-010-0802-8; http://link.springer.com/10.1007/s13233-010-0802-8; http://link.springer.com/content/pdf/10.1007/s13233-010-0802-8; http://link.springer.com/content/pdf/10.1007/s13233-010-0802-8.pdf; http://link.springer.com/article/10.1007/s13233-010-0802-8/fulltext.html; https://dx.doi.org/10.1007/s13233-010-0802-8; https://link.springer.com/article/10.1007/s13233-010-0802-8; http://www.springerlink.com/index/10.1007/s13233-010-0802-8; http://www.springerlink.com/index/pdf/10.1007/s13233-010-0802-8
Springer Science and Business Media LLC
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