Synthesis of thermo-sensitive polyelectrolyte complex nanoparticles from CS-g-PNIPAM and SA-g-PNIPAM for controlled drug release
Macromolecular Research, ISSN: 2092-7673, Vol: 22, Issue: 9, Page: 1004-1011
2014
- 37Citations
- 23Captures
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Article Description
In this paper, thermo-sensitive polyelectrolyte complex nanoparticles assembled from chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAM) and sodium alginate-graft-poly(N-isopropylacrylamide) (SA-g-PNIPAM) were prepared for entrapment and release of 5-fluorouracil (5-FU). The morphology and size of the nanoparticles were observed by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The polyelectrolyte complex nanoparticles showed a narrow size distribution. The hydrogen bonding interactions between nanoparticles and 5-FU, which was determined by fourier-transformed infrared spectroscopy (FTIR), increased drug loading. Glutaraldehyde, as a cross-linking agent, reinforced the nanoparticle structure and decreased the burst drug release. When changing temperature, pH, or ionic strength, a sustained and controlled drug release was observed. The novel complex nanoparticles with environmentally sensitive properties are expected to be useful in the field of intelligent drug delivery system.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84910039650&origin=inward; http://dx.doi.org/10.1007/s13233-014-2134-6; http://link.springer.com/10.1007/s13233-014-2134-6; http://link.springer.com/content/pdf/10.1007/s13233-014-2134-6; http://link.springer.com/content/pdf/10.1007/s13233-014-2134-6.pdf; http://link.springer.com/article/10.1007/s13233-014-2134-6/fulltext.html; https://dx.doi.org/10.1007/s13233-014-2134-6; https://link.springer.com/article/10.1007/s13233-014-2134-6
Springer Science and Business Media LLC
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