Curcumin derivative HBC induces autophagy through activating AMPK signal in A549 cancer cells
Molecular and Cellular Toxicology, ISSN: 2092-8467, Vol: 11, Issue: 1, Page: 29-34
2015
- 11Citations
- 6Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Curcumin exhibits growth-suppressive activity against a variety of cancer cells, but low bioavailability restricts its application in chemotherapeutic trials. A synthetic curcumin derivative hydrazinobenzoylcurcumin (HBC) had been indicated that it could inhibit cell growth in A549 lung cancer cells via cell autophagy in our previous report. The present research aims to investigate the effect of HBC on the AMP-activated protein kinase (AMPK) signaling and whether AMPK signaling is involved in HBC-induced autophagy in A549 cells. The autophagy inhibitor 3-MA was used to block the inhibitory effect of HBC on the growth of A549 cells by acridine orange assay. The phosphorylations of AMPK and its downstream factor Acetyl CoA Carboxylase (ACC) were characterized in HBCtreated A549 cells with western blot analysis. Moreover, pharmacological inhibition of the AMPK signaling pathway by Compound C impairs the autophagyinducing effect of HBC. Our data indicates that HBC could activate the AMPK signal and induce AMPKmediated autophagy, which plays an important role in the inhibiting effect of HBC in A549 cells.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84926318514&origin=inward; http://dx.doi.org/10.1007/s13273-015-0004-8; http://link.springer.com/10.1007/s13273-015-0004-8; http://link.springer.com/content/pdf/10.1007/s13273-015-0004-8; http://link.springer.com/content/pdf/10.1007/s13273-015-0004-8.pdf; http://link.springer.com/article/10.1007/s13273-015-0004-8/fulltext.html; https://dx.doi.org/10.1007/s13273-015-0004-8; https://link.springer.com/article/10.1007/s13273-015-0004-8
Springer Science and Business Media LLC
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know