FXYD3 promotes the proliferation, migration, and invasion of pancreatic cancer cells by regulating the cGMP-PKG signaling pathway
Molecular and Cellular Toxicology, ISSN: 2092-8467, Vol: 18, Issue: 3, Page: 371-381
2022
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Background: FXYD3, as a regulator of ion transporting membrane protein, plays a key role in the progression of various cancers. It is reported that FXYD3 is overexpressed in pancreatic cancer, but the molecular mechanism of FXYD3 regulating pancreatic cancer is not well illustrated. Objective: The aim of this work was to study the role of FXYD3 in pancreatic cancer and the underlying mechanism. Results: The expression of FXYD3 was aberrantly high in pancreatic cancer tissues and cells compared to the controls. High expression of FXYD3 was associated with the patient’s poor prognosis and promoted the proliferation, migration, and invasion of pancreatic cancer cells. Furthermore, FXYD3 expression was positively correlated with the activation of cGMP-PKG signaling pathway, and FXYD3 could enhance cGMP content. Conclusion: Our study speculated that FXYD3 was likely to activate the cGMP-PKG signaling pathway to promote tumor proliferative activity. These findings contribute to understanding the role of FXYD3 in the development of pancreatic cancer and provide new therapeutic targets for its treatment.
Bibliographic Details
Springer Science and Business Media LLC
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