Current Prophylactic Medications for Migraine and Their Potential Mechanisms of Action
Neurotherapeutics, ISSN: 1878-7479, Vol: 15, Issue: 2, Page: 313-323
2018
- 86Citations
- 220Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations86
- Citation Indexes83
- 83
- CrossRef71
- Policy Citations3
- Policy Citation3
- Captures220
- Readers220
- 220
Review Description
A relatively high number of different medications is currently used for migraine prevention in clinical practice. Although these compounds were initially developed for other indications and differ in their mechanisms of action, some general themes can be identified from the mechanisms at play. Efficacious preventive drugs seem to either suppress excitatory nervous signaling via sodium and/or calcium receptors, facilitate GABAergic inhibition, reduce neuronal sensitization, block cortical spreading depression and/or reduce circulating levels of CGRP. We here review such mechanisms for the different compounds.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1878747923015635; http://dx.doi.org/10.1007/s13311-018-0621-8; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85045645288&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/29671241; https://linkinghub.elsevier.com/retrieve/pii/S1878747923015635; https://dx.doi.org/10.1007/s13311-018-0621-8
Elsevier BV
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