Associations of the MTNR1B rs10830963 and PPARG rs1801282 variants with gestational diabetes mellitus: A meta-analysis

Background: Single nucleotide variants (SNVs) of functional diabetogenic genes are also involved in the pathogenetic mechanism of gestational diabetes mellitus (GDM). This study aimed at assessing associations of GDM with MTNR1B and PPARG gene variants in different racial populations. Methods: Literatures from PubMed and Embase databases were searched. Data were abstracted by two reviewers, and a consensus method was used to resolve disagreements. All reviewers worked independently. Twenty-one eligible literatures were enrolled by our data selection strategies, and heterogeneity, subgroup, sensitivity, and publication bias analysis. Results: G allele variant of rs10830963 was significantly associated with an increasing risk of GDM (GG + CG vs. CC: pooled OR = 1.52, 95% CI = 1.37–1.69, p < 0.001; GG vs. CG + CC: pooled OR = 1.49, 95% CI = 1.37–1.62, p < 0.001; G vs. C: pooled OR = 1.40, 95% CI = 1.30–1.52, p < 0.001). Further subgroup analysis showed the risk G allele were significantly associated with the GDM risk in women from Europe, Asia, and America, while European women carrying the G allele had a higher risk of GDM (G vs. C: pooled OR = 1.617, 95% CI = 1.46–1.79, p < 0.001) than the other regional ones. No significant correlation between the G allele of PPARG rs1801282 (C > G) SNV risk of GDM, which is consistent with some former studies. Conclusions: MTNR1B rs10830963(C > G) significantly increases the risk of GDM in Europeans, Asians, and Americans. G allele carriers in European population were confirmed a higher risk of GDM than Asian and American populations. No association between GDM and PPARG rs1801282 SNV indicates further validation may be needed.