Environmental and Genetic Factors Controlling Burkholderia pseudomallei Persister Phenotypes
Current Tropical Medicine Reports, ISSN: 2196-3045, Vol: 4, Issue: 3, Page: 111-116
2017
- 4Citations
- 11Captures
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Review Description
Purpose of Review: Burkholderia pseudomallei, the causative agent of the severe disease melioidosis, can form persister cells, which can survive under high-dose antibiotic challenge complicating the treatment of the disease. In this review, we discuss our current knowledge on the formation of persister cells in B. pseudomallei. Recent Findings: Recent studies suggest that growth-limiting conditions such as nutrient and oxygen limitation, as well as antibiotic challenge, can lead to formation of persister cells. Among the diverse set of genes that can contribute to persister cell formation, toxin-antitoxin pairs are the most studied and have been shown to contribute to persister cell formation in B. pseudomallei. Summary: B. pseudomallei infections result in high relapse rate after recovery from melioidosis. Such relapses may be facilitated by reactivation of the B. pseudomallei persister cells. Therefore, understanding the environmental and genetic factors that contribute to persistence is critical to develop effective treatment strategies for melioidosis.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85048542552&origin=inward; http://dx.doi.org/10.1007/s40475-017-0116-4; http://link.springer.com/10.1007/s40475-017-0116-4; http://link.springer.com/content/pdf/10.1007/s40475-017-0116-4.pdf; http://link.springer.com/article/10.1007/s40475-017-0116-4/fulltext.html; https://dx.doi.org/10.1007/s40475-017-0116-4; https://link.springer.com/article/10.1007/s40475-017-0116-4
Springer Science and Business Media LLC
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