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The study of the concentration increasing effect in the combination of zinc ion with human growth hormone by molecular dynamics simulation

Iranian Journal of Science and Technology, Transaction A: Science, ISSN: 2364-1819, Vol: 41, Issue: 2, Page: 329-335
2017
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Metrics Details

  • Citations
    2
    • Citation Indexes
      2

Article Description

In this study, we examined the stability of human growth hormone (hGH) in the presence of two different concentrations of zinc ions at the molecular level using molecular dynamics simulation for 30 ns. Analysis of the obtained trajectory of the molecular dynamics simulation (root mean square deviation, root mean square fluctuation, DSSP, hydrogen bond, radius of gyration, solvent accessible surface area and dynamic cross-correlation map) shows that the hGH protein structure is stabilized in the presence of Zn ions, especially in 0.025 M of zinc ions. Our findings are in good agreement with our previous experimental study.

Bibliographic Details

S. Tayyebi; E. Tazikeh-Lemeski

Springer Science and Business Media LLC

Chemistry; Mathematics; Agricultural and Biological Sciences; Physics and Astronomy; Earth and Planetary Sciences

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