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In vivo safety assessment of a polyherbal formulation (Stress WIN) proposed for clinical hypertension management

Discover Applied Sciences, ISSN: 3004-9261, Vol: 6, Issue: 10
2024
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Indian Institute of Technology at Banaras Hindu University Researchers Focus on Hypertension [In vivo safety assessment of a polyherbal formulation (Stress WIN) proposed for clinical hypertension management]

2024 OCT 14 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Cardiovascular Daily -- Investigators discuss new findings in hypertension. According to news

Article Description

Herbal treatments are nowadays considered dietary supplements and nutraceuticals for health maintenance and alternative/complementary therapy. A large range of herbal medications worldwide can easily be accessible in the local market. The polyherbal formulation (Stress WIN) containing Ashwagandha (Withania somnifera L. Dunal), Pushkarmoola (Inula racemosa Hook. F.), and Jatamansi (Nardostachys jatamansi (D. Don) DC.) root has been used empirically in the management of hypertension. However, toxicity data for the StressWIN is not available yet. The present study aims to evaluate the StressWIN’s safety profile by 28 days of repeated dose oral toxicity in Wistar rats. Rats received different doses (500 mg/kg/day, 1000 mg/kg/day, and 2000 mg/kg/day) of StressWIN, for 28 days. The study was conducted in compliance with the OECD guideline 423. No significant differences were observed in hematological and biochemical parameters as compared to the control group (p > 0.05). Histopathological studies revealed no significant alterations in the macroscopic and microscopic architecture of the liver, kidney, heart, and spleen of the StressWIN treated groups in comparison to the control group (p > 0.05). Findings from the present study suggest that StressWIN supplementation has not shown any side effects in terms of sub-acute toxicity in both male and female rats. These findings indicated no observed adverse effect level (NOAEL) of StressWIN was higher than 2000 mg/kg/day.

Bibliographic Details

Somesh Agarwal; Vinod Tiwari; Anirban Roy; Amaresh Kumar Singh; Poonam Pal; A. Kartika; Sanjeev Kumar; Rajesh Sharma

Springer Science and Business Media LLC

Chemical Engineering; Earth and Planetary Sciences; Engineering; Environmental Science; Materials Science; Physics and Astronomy

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