Genetic mechanisms of resistance to acyclovir in herpes simplex virus
The American Journal of Medicine, ISSN: 0002-9343, Vol: 73, Issue: 1, Page: 361-368
1982
- 5Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations5
- Citation Indexes5
- CrossRef5
- Captures3
- Readers3
Article Description
Resistance to acyclovir in herpes simplex virus (HSV) is mediated by two genetic loci on the herpes virus genome: viral thymldine kinase and DNA polymerase. Passage of HSV in the presence of 10 μ M or 2 μ M acyclovir readily coselects for virus deficient in the expression of viral thymidine kinase and resistance to acyclovir. Other workers have shown that passage of HSV in serum-starved cells in the presence of acyclovir selects for a mutant virus possessing a thymidine kinase with an altered substrate specificity and inability to phosphorylate acyclovir.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0002934382901231; http://dx.doi.org/10.1016/0002-9343(82)90123-1; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0019906766&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/6285723; https://linkinghub.elsevier.com/retrieve/pii/0002934382901231; http://dx.doi.org/10.1016/0002-9343%2882%2990123-1; https://dx.doi.org/10.1016/0002-9343%2882%2990123-1
Elsevier BV
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