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Genetic mechanisms of resistance to acyclovir in herpes simplex virus

The American Journal of Medicine, ISSN: 0002-9343, Vol: 73, Issue: 1, Page: 361-368
1982
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Article Description

Resistance to acyclovir in herpes simplex virus (HSV) is mediated by two genetic loci on the herpes virus genome: viral thymldine kinase and DNA polymerase. Passage of HSV in the presence of 10 μ M or 2 μ M acyclovir readily coselects for virus deficient in the expression of viral thymidine kinase and resistance to acyclovir. Other workers have shown that passage of HSV in serum-starved cells in the presence of acyclovir selects for a mutant virus possessing a thymidine kinase with an altered substrate specificity and inability to phosphorylate acyclovir.

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