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Transmembrane ionic transport systems and hypertension

The American Journal of Medicine, ISSN: 0002-9343, Vol: 84, Issue: 1, Page: 3-9
1988
  • 5
    Citations
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Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    5
    • Citation Indexes
      5
      • CrossRef
        5

Article Description

Various systems contribute to the regulation of intracellular calcium. The most important are: (1) the voltage-dependent calcium channel; (2) sodium/calcium exchange, resulting in a correlation between intracellular sodium and calcium; (3) plasma membrane calcium ATPase; and (4) the inositol triphosphate-regulated channel, releasing calcium from the endoplasmic and sarcoplasmic reticulum stores. The essential properties of these different systems, their pharmacologic features, and their regulation by various agonists (beta- and alpha-adrenergic angiotensin-type peptides, etc.) must be considered both for an understanding of the pathophysiology of hypertension and for its treatment.

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