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Postnatal increase in histone H1a in the rat pancreas

Archives of Biochemistry and Biophysics, ISSN: 0003-9861, Vol: 179, Issue: 2, Page: 715-717
1977
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Article Description

Adult rat pancreas contains an unusually high amount of histone H1a; H1aH1 ratio = 0.27. Histone H1a is not detectable in embryonic or newborn rat pancreas. This histone begins to appear at about 1 week postnatally and reaches the adult level about 5 weeks after birth. There is an inverse relationship between the appearance of histone H1a and DNA synthesis, as indicated by the nuclear labeling index after [ 3 H]thymidine autoradiography.

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