Modified oscillation behavior and decreased d -3-hydroxybutyrate dehydrogenase activity in diabetic rat liver mitochondria
Archives of Biochemistry and Biophysics, ISSN: 0003-9861, Vol: 214, Issue: 2, Page: 581-588
1982
- 21Citations
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Metrics Details
- Citations21
- Citation Indexes21
- 21
- CrossRef20
Article Description
One month after induction of diabetes in adult white rats with streptozotocin or 4–10 months after its induction by pancreatectomy (in every case glycemia was over 3 g/liter), the following alterations were observed in liver mitochondria: (a) a decrease of amplitude and an increase of the damping factor of volume oscillations induced by potassium ions and valinomycin; (b) a 50% decrease of d -3-hydroxybutyrate dehydrogenase (HBD) activity in mitochondria disrupted by repeated freeze-thawing; (c) a similar decrease in the rate of d -3-hydroxybutyrate oxidation by intact mitochondria; (d) a significant increase of cytochrome oxidase activity and cytochrome aa 3 content. Measurement of succinate dehydrogenase and NADH dehydrogenase activity, the cytochrome b, c 1, and c content, and the P:O ratio for mitochondria oxidizing d -3-hydroxybutyrate did not reveal significant differences between control and diabetic rat mitochondria. In the streptozotocin-injected rats, the variation of HBD activity and the modification of the mitochondrial oscillation pattern were time-dependent phenomena, both effects reaching their maximal expression about 1 month after the onset of diabetes. The variation of HBD activity followed a biphasic course, since it rose to above the control level during the first 2 weeks of diabetes, then fell progressively to about half the control value after the third week. Treatment of diabetic rats with NPH insulin (5 IU twice daily, for 3 days, reinforced by the same dose 45 min before sacrifice) restored the mitochondrial oscillation pattern, HBD activity, and rate of d -3-hydroxybutyrate oxidation by intact mitochondria to their normal values.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0003986182900637; http://dx.doi.org/10.1016/0003-9861(82)90063-7; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0020405095&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/6284028; https://linkinghub.elsevier.com/retrieve/pii/0003986182900637; http://dx.doi.org/10.1016/0003-9861%2882%2990063-7; https://dx.doi.org/10.1016/0003-9861%2882%2990063-7
Elsevier BV
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