Enhanced sensitivity to oxidative stress in Cu,ZnSOD depleted rat erythrocytes
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, ISSN: 0005-2760, Vol: 1123, Issue: 3, Page: 291-295
1992
- 8Citations
- 2Captures
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef8
- Captures2
- Readers2
Article Description
The effects on red blood cells of superoxide dismutase (Cu,ZnSOD) depletion, induced by feeding Wistar rats with a copper deficient diet, were investigated. SOD depleted red blood cells were more sensitive to peroxidation and to hemolysis than normal cells when exposed to tert -butylhydroperoxide ( t -BOOH). Membranes isolated from SOD depleted cells showed a lower content of vitamin E and higher (Na +, K + ) and Mg 2+ ATPase activities. These results support the view that superoxide dismutase plays an important role in cellular oxidative metabolism.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/000527609290009K; http://dx.doi.org/10.1016/0005-2760(92)90009-k; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0026548570&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/1311207; http://linkinghub.elsevier.com/retrieve/pii/000527609290009K; http://api.elsevier.com/content/article/PII:000527609290009K?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:000527609290009K?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/000527609290009K; http://dx.doi.org/10.1016/0005-2760%2892%2990009-k; https://dx.doi.org/10.1016/0005-2760%2892%2990009-k
Elsevier BV
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