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Stimulation by ATP of cytosol-type δ-aminolevulinate synthase of rat liver

Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 80, Issue: 2, Page: 370-376
1978
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Article Description

ATP stimulated the activity of δ-aminolevulinate synthase of rat liver cytosol. The enzyme exhibited negative cooperativity with respect to glycine, one of the substrates, and was inhibited by succinyl-CoA, the other substrate. ATP converted the negative cooperativity to the normal saturation kinetics and released the substrate inhibition by succinyl-CoA. These actions of ATP appear to bring about the stimulation of the enzyme.

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