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Biochemical evidence for a deficiency of vitamin B 6 in subjects reacting to monosodium L-glutamate by the Chinese Restaurant Syndrome

Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 100, Issue: 3, Page: 972-977
1981
  • 13
    Citations
  • 0
    Usage
  • 4
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    13
    • Citation Indexes
      13
  • Captures
    4

Article Description

The concept of this research was that monosodium L-glutamate(MSG), an amino acid, might reveal a deficiency of vitamin B 6 by the neurological effects known as the Chinese Restaurant Syndrome (CRS). Tryptophan, an amino acid, is known to reveal a deficiency of B 6 by excretion products. Basal specific activities (S.A.'s) of EGOT were determined on 158 students on no B 6 supplement. Of 27 with extraordinarily low S.A.'s (<0.26 μmoles pyruvate/hr/10 8 erythrocytes), 12 responded to MSG. By double blind, 3 of the 12 again revealed CRS after placebo to B 6 ; 8 of the other 9 showed no symptoms to MSG after supplemental B 6. These results show, p<0.01, that supplemental B 6 effectively prevents occurrence of CRS in responders to MSG.

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