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Phosphocitrate inhibition of 45 Ca 2+ uptake in rat aortic smooth muscle cells in primary culture

Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 131, Issue: 2, Page: 793-799
1985
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Phosphocitrate inhibits 45 Ca 2+ uptake by rat aortic smooth muscle cells in primary culture. Unlike the Ca 2+ channel blocking effect of diltiazem, the phosphocitrate effect is neither time dependent nor reliant on a depolarized membrane. Phosphocitrate and diltiazem together in maximum inhibitory concentration show an additive effect. The data suggest that different Ca 2+ uptake mechanisms are involved. The potential exists for phosphocitrate to have a therapeutic role in atherogenesis through modulating Ca 2+ movements in arterial smooth muscle.

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