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Biological activities of catfish glucagon and glucagon-like peptide

Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 143, Issue: 1, Page: 87-92
1987
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Article Description

The ability of catfish glucagon and glucagon-like peptide to bind and activate mammalian glucagon receptors was investigated. Neither catfish peptide binds to glucagon receptors of rat liver, hypothalamus or pituitary. Neither stimulates adenylate cyclase activity in liver membranes. Catfish glucagon fails to activate adenylate cyclase in hypothalamic or pituitary membranes in contrast to mammalian glucagon. However, catfish glucagon-like peptide does stimulate hypothalamic and pituitary adenylate cyclase (EC 50 ∼ 1 pM) possibly through mammalian glucagon-like peptide receptors.

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