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2,3-bisphosphoglycerate protects mitochondrial and cytosolic proteins from proteolytic inactivation

Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 142, Issue: 3, Page: 680-687
1987
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2,3-bisphosphoglycerate at physiological concentration similar to that found in many tissues protects effectively ornithine transcarbamoylase (OTC) from proteolytic inactivation by broken lysosomes. 2,3-bisphosphoglycerate protects also many other mitochondrial and cytosolic proteins, such as glutamate dehydrogenase (GDH) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), from proteolysis by broken lysosomes and other proteases. It is, thus, suggested that 2,3-bisphosphoglycerate may play an important role in the control of the degradative rates of some proteins, which may explain its high concentration in certain cells.

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