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A new family of 2-hydroxyacid dehydrogenases

Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 165, Issue: 3, Page: 1371-1374
1989
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Article Description

The NADH-dependent hydroxypyruvate reductase from cucumber and the pdxB gene product of E. coli display significant homology to E. coli D-3-phosphoglycerate dehydrogenase. In contrast, these proteins do not display much similarity with other oxidoreductases or with other 2-hydroxyacid dehydrogenases in particular. On the basis of their relatedness and the structure of their substrates, these three enzymes constitute a new family of 2-hydroxyacid dehydrogenases distinct from malate and lactate dehydrogenase.

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